By Gerd Plewig Prof. Dr., Albert M. Kligman M.D., Ph.D. (auth.)
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The lipid is found extracellulady in clefts between the corneocytes and in the channels which conduct it to the surface. Lipid droplets within the corneocytes can only bee seen by electron microscopy Below Left Lipid-laden cells (sebocytes). Electron microscopic view of mature lipid cells of the sebaceous glands shortly before their rupture. (Electron microscopy, x 6900) Right Human sebum. Sebum is a yellowish, oily liquid at skin temperature. This was collected by ether extraction from the scalp Courtesy of Kenneth 1.
J Invest Dermatol 54: 487--495 Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT (1988) Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. J Invest Dermatol 90:350-353 Stewart ME (1992) Sebaceous gland lipids. Semin Dermatol 11: 100-105 Dilution of the epidermal lipids of the follicular epithelium by sebaceous lipids. FFA free fatty acids, WE wax esters, TG triglycerides, sa squalene Not only ceramides but also other epidermal lipids such as free sterols are reduced in acne comedones.
Of the scalp; and finally, there are huge sebaceous follicles, excluexactly scientific. sively found in humans. The products of the giant multilobulated glands of the latter flow into a deep, wide canal to which Anatomy of Sebaceous Glands a tiny, trivial hair unit is attached. These With the exception of in the palms and sebaceous gland follicles are particularly the soles, sebaceous glands are found ev- abundant in the face, ear canal, V-shaped erywhere in human skin. Their number parts of the chest and back, and on the varies greatly in different body sites.