Read e-book online Advances in Neurochemistry: Volume 3 PDF

By Neil Raymond Sims, Patrick Robert Carnegie (auth.), B. W. Agranoff, M. H. Aprison (eds.)

The unique premise of the Editors in beginning this sequence used to be that there existed a readership ofneurochemists with enormous biochemical again­ flooring who could utilize a chain devoted to either new increase­ ments and really good reports in neurochemistry. Having chosen our authors, we've provided them almost whole freedom to mirror and speculate in a box during which they've got completed prominence. The reaction to the 1st volumes has been profitable. the current one maintains during this culture. whereas we haven't tried to submit really expert volumes, the current quantity comprises a little bit similar chapters (Chapters four and five, at the position of amino acid neurotransmitters). the 1st 3 chapters study 3 various techniques, every one of present curiosity, in neurochemi­ cal ways to the molecular bases of neuronal and glial constitution. B. W. Agranoff M. H. Aprison vii CONTENTS bankruptcy 1 2',3'-CYCUC NUCLEOTIDE 3'-PHOSPHODIESTERASE NEIL RAYMOND SIMS AND PATRICK ROBERT CARNEGIE 1. creation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Assay of CNPase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three 2. 1. want for Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three 2. 2. comparability of Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three three. organization of CNPase with Myelin . . . . . . . . . . . . . . . . . . . . . . . 7 three. 1. old. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 three. 2. Subcellular Fractionation. . . . . . . . . . . . . . . . . . . . . . . . . . . . eight three. three. improvement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . eight three. four. Mutant Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine three. five. Use as a Myelin Marker . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 three. 6. Myelin-Related Fractions and Peripheral Nerve Myelin. eleven four. CNPase in Nonmyelin Fractions. . . . . . . . . . . . . . . . . . . . . . . . . . thirteen five. Activation and Isolation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . thirteen five. 1. advent. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . thirteen five. 2. Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 five. three. Solubilization and Fractionation. . . . . . . . . . . . . . . . . . . . . . 15 6. houses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6. 1. Substrate Specificity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Mitchell, R. , 1970, The identity of a myelin-like fraction isolated from developing braid, Biochem,. J. 120:635-642. Agrawal, R. , Trotter, J. , Mitchell, R. , and Burton, R. , 1973, Criteria for identifying a myelin-like fraction from developing brain, Biochem. J. 136:1117-1119. Agrawal, R. , Trotter, J. , Burton, R. , and Mitchell, R. , 1974, Metabolic studies on myelin. Evidence for a precursor role of a myelin subfraction, Biochem. J. 140:99-109. Banik, N. , and Davison, A. , 1969, Enzyme activity and composition of myelin and subcellular fractions in the developing rat brain, Biochem.

1972). , 1974). The possible association of CNPase with the primary defect in SSPE requires further investigation. When nerves are sectioned Wallerian degeneration results, in which the axon and associated myelin sheath distal to the section rapidly degenerate while the proximal portion undergoes only temporary demyelination (Adams and Liebowitz, 1969). , 1974). 6. Tumors and Cultured Cells In addition to the conditions outlined in Table 3, a number of other pathological situations have also been studied.

40:419-436. Wassenaar, J. , and Kroon, A. , 1973, Effects of triethyltin on different ATPases, 5'nucleotidase and phosphodiesterases in grey and white matter of rabbit brain and their relation with brain edema, Eur. Neurol. 10:349-370. Whitfeld, P. , Heppel, L. , hIld Markham, R, 1955, The enzymic hydrolysis of ribonucleoside-2' : 3'-phosphates, Biochem. J. 60:15-19. , Miller, S. , Benjamins, J. , Krigman, M. , 1976, Myelin synthesis during postnatal nutritional deprivation and subsequent rehabilitation.

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