Download e-book for iPad: Aging is a group-selected adaptation: theory, evidence, and by Joshua Mitteldorf

By Joshua Mitteldorf

Because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary concept, particularly within the sector of genetics. simultaneously, a technology of multilevel choice has came upon its position within the evolutionary literature. the writer means that proof warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic conception of senescence, wherein getting older has Read more...

summary: because the Nineteen Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary idea, in particular within the quarter of genetics. at the same time, a technological know-how of multilevel choice has stumbled on its position within the evolutionary literature. the writer means that proof warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic conception of senescence, wherein getting older has been affirmatively chosen since it degrees the loss of life fee through the years, assisting to stabilize inhabitants dynamics and stop extinctions

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K. Crawford and C. Kenyon, Timing requirements for insulin/IGF-1 signaling in C. elegans. Science, 2002. 298(5594): p. 830-4. 57. Hsin, H. and C. Kenyon, Signals from the reproductive system regulate the life span of C. elegans. Nature, 1999. 399(6734): p. 362-366. 58. , The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. , 1986. 116(4): p. 641-54. 59. , Dietary modulation of reproductive function, In: Modulation of Aging Processes by Dietary Restriction, B.

357-377. 26. , Protein restriction (PR) and caloric restriction (CR) compared: effects on DNA damage, carcinogenesis and oxidative damage. Mutation Research/DNAging, 1993. 295(4): p. 165-179. 27. , Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell, 2008. 7(5): p. 681-7. 28. , Low methionine ingestion by rats extends life span. J. , 1993. 123(2): p. 269-274. 20 Aging is a Group-Selected Adaptation 29. , Effects of intermittent feeding upon growth and life span in rats.

Aging is able to complement the death rate from starvation or disease, because it only adds to the death rate when the other threats to the population are low enough that individuals are living long enough that aging can kick in. In other words, when everyone is dying of starvation (or of an epidemic, earthquake, or forest fire), they are not dying of old age. Aging has little effect on the death rate at such times, but only when these other threats to life have backed off sufficiently that some animals can live into old age.

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